Vascular development entails multiple cell‐fate decisions to specify a diverse array of vascular structures. Notch proteins are signaling receptors that regulate cell‐fate determination in a variety of cell types. The finding that Notch genes are robustly expressed in the vasculature suggests roles for Notch in guiding endothelial and associated mural cells through the myriad of cell‐fate decisions needed to form the vasculature. In fact, mice with defects in genes encoding Notch, Notch ligands, and components of the Notch signaling cascade invariably (...) display vascular defects. Human Notch genes are linked to Alagille's Syndrome, a developmental disorder with vascular defects, and CADASIL, a cerebral arteriopathy. Studies in zebrafish, mice and humans indicate that Notch works in conjunction with other angiogenic pathways to pattern and stabilize the vasculature. Here, we will focus on established functions for Notch in vascular remodeling and arterial/venous specification and more speculative roles in vascular homeostasis and organ‐specific angiogenesis. BioEssays 26:225–234, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The mining and energy industries present unique challenges to engineers, who must navigate sometimes competing responsibilities and codes of conduct, such as personal senses of right and wrong, professional ethics codes, and their employers’ corporate social responsibility policies. Corporate social responsibility is the current dominant framework used by industry to conceptualize firms’ responsibilities to their stakeholders, yet has it plays a relatively minor role in engineering ethics education. In this article, we report on an interdisciplinary pedagogical intervention in a petroleum (...) engineering seminar that sought to better prepare engineering undergraduate students to critically appraise the strengths and limitations of CSR as an approach to reconciling the interests of industry and communities. We find that as a result of the curricular interventions, engineering students were able to expand their knowledge of the social, rather than simply environmental and economic dimensions of CSR. They remained hesitant, however, in identifying the links between those social aspects of CSR and their actual engineering work. The study suggests that CSR may be a fruitful arena from which to illustrate the profoundly sociotechnical dimensions of the engineering challenges relevant to students’ future careers. (shrink)

Background The allocation of scarce deceased donor kidneys is a complex process. Transplant providers are increasingly relying on constructs such as frailty and cognitive function to guide kidney transplant (KT) candidate selection. Patient views of the ethical issues surrounding the use of such constructs are unclear. We sought to assess KT candidates’ attitudes and beliefs about the use of frailty and cognitive function to guide waitlist selection.Methods KT candidates were randomly recruited from an ongoing single-center cohort study of frailty and (...) cognitive function. Semi-structured interviews were conducted, and thematic analysis was performed. Inductively derived themes were mapped onto bioethics principles.Results Twenty interviews were conducted (65% contact rate, 100% participation rate) (60% male; 70% White). With respect to the use of frailty and cognitive function in waitlisting decisions, four themes emerged in which participants: (1) valued maximizing a scarce resource (utility); (2) prioritized equal access to all patients (equity); (3) appreciated a proportional approach to the use of equity and utility (precautionary utility); and (4) sought to weigh utility- and equity-based concerns regarding social support. While some participants believed frailty and cognitive function were useful constructs to maximize utility, others believed their use would jeopardize equity. Patients were uncomfortable with using single factors such as frailty or cognitive impairment to deny someone access to transplantation; participants instead encouraged using the constructs to identify opportunities for intervention to improve frailty and cognitive function prior to KT.Conclusions KT candidates’ values mirrored the current allocation strategy, seeking to balance equity and utility in a just manner, albeit with conflicting viewpoints on the appropriate use of frailty and cognitive impairment in waitlisting decisions. (shrink)

Courts play a central role in legal and political processes in many countries in the common law world. Legal actors have a stake in making sure that legal processes and procedures are perceived as legitimate, both by the general population and professionals. Civil procedure, in both common law and civilian legal systems, has been historically known for its complexity. This article presents a body of empirical research about courts and procedural rules, and their role in different societies. It also analyzes (...) research and states how it has been used in policy debates and reforms. In addition, it discusses the question of the demand and supply for empirical research about rules of procedure and courts, and explores the difficulty of carrying out empirical research that goes beyond a focus on the institutional needs of the courts themselves and the reformers interested in their own court-reform agendas. (shrink)

This article introduces the concept of alternate dispute resolution, and discusses its baseline measure and comparison process. Empirical research on ADR falls into two categories, empirically descriptive work and empirically comparative work. Litigation varies across legal systems and changes through time, just as does ADR. Many studies have documented and described patterns of uses of particular forms of dispute resolution. These studies are designed to explore variations of behavior or outcomes within a particular process. Several commentators have observed that formal (...) litigation and various forms of ADR, such as, mediation, private adjudication-arbitration, and other hybrid forms compete with and affect each other. Recent extensions of ADR suggest that the domain of dispute-resolution research is far more capacious than assessing how disputes are managed in lawsuits or courts. (shrink)

Parental refusal of a recommended treatment is not an uncommon scenario in the neonatal intensive care unit. These refusals may be based upon the parents’ perceptions of their child’s projected quality of life. The inherent subjectivity of quality of life assessments, however, can exacerbate disagreement between parents and healthcare providers. We present a case of parental refusal of surgical intervention for necrotizing enterocolitis in an infant with Bartter syndrome and develop an ethical framework in which to consider the appropriateness of (...) parental refusal based upon an infant’s projected quality of life. (shrink)

Next SectionPublic and healthcare professionals differ in their attitudes towards euthanasia and physician-assisted suicide (PAS), the legal status of which is currently in the spotlight in the UK. In addition to medical training and experience, religiosity, locus of control and patient characteristics (eg, patient age, pain levels, number of euthanasia requests) are known influencing factors. Previous research tends toward basic designs reporting on attitudes in the context of just one or two potentially influencing factors; we aimed to test the comparative (...) importance of a larger range of variables in a sample of nursing trainees and non-nursing controls. One hundred and fifty-one undergraduate students (early-stage nursing training, late-stage nursing training and non-nursing controls) were approached on a UK university campus and asked to complete a self-report questionnaire. Participants were of mixed gender and were on average 25.5 years old. No significant differences in attitude were found between nursing and non-nursing students. There was a significant positive correlation between higher religiosity and positive attitude toward euthanasia (r=0.19, p<0.05) and a significant negative relationship between internal locus of control and positive attitude toward PAS (r=−0.263, p<0.01). Multivariate analyses revealed differing predictor models for attitudes towards euthanasia and PAS, and confirm the importance of individual differences in determining these attitudes. The unexpected direction of association between religiosity and attitudes may reflect a broader cultural shift in attitudes since earlier research in this area. Furthermore, these findings suggest it possible that experience, more than training itself, may be a bigger influence on attitudinal differences in healthcare professionals. (shrink)

The performance appraisal process is increasingly seen as a key link between employee behaviour and an organization’s strategic objectives. Unfortunately, performance reviews often fail to change how people work, and dissatisfaction with the appraisal process has been associated with general job dissatisfaction, lower organizational commitment, and increased intentions to quit. Recent research has identified a number of factors related to reactions to performance appraisals in general and appraisal satisfaction in particular. Beyond the appraisal outcome itself, researchers have found that appraisal (...) reactions are affected by perceptions of fairness and the relationship between the supervisor and the employee. To explain the relationships among these factors, the present article proposes a moral cognition perspective. We suggest that employees judge a performance appraisal from the perspective of its moral justifiability, and that appraisal reactions will be determined, at least in part, by the perceived moral justifiability of the process. The proposal was supported by results from a survey of government employees using measures of performance ratings, leader–member exchange, perceived utility, and organizational justice. (shrink)

Understanding why individuals opt out of living donation is crucial to enhancing protections for all living donors and to identify modifiable barriers to donation. We developed an ethical approach to conducting research on individuals who opted out of living kidney donation and applied it in a small-scale qualitative study at one US transplant centre. The seven study participants had varied reasons for opting out, the most prominent of which was concern about the financial burden from lost wages during the postoperative (...) period. Several reported feeling alone during their decision-making process. Although no participants used an alibi, a centre-provided statement of non-eligibility to donate, all believed that centres should offer alibis to help preserve donor autonomy. Given the complexity of participants' decisions and the emotions they experienced before and after deciding not to donate, we suggest approaches for independent living donor advocates to support this population. This study demonstrates that research on individuals who opt out of donation is feasible and yields valuable insight into methods to improve the evaluation experience for potential living donors. (shrink)

BackgroundResponsive neurostimulation has been utilized as a treatment for intractable epilepsy. The RNS System delivers stimulation in response to detected abnormal activity, via leads covering the seizure foci, in response to detections of predefined epileptiform activity with the goal of decreasing seizure frequency and severity. While thalamic leads are often implanted in combination with cortical strip leads, implantation and stimulation with bilateral thalamic leads alone is less common, and the ability to detect electrographic seizures using RNS System thalamic leads is (...) uncertain.ObjectiveThe present study retrospectively evaluated fourteen patients with RNS System depth leads implanted in the thalamus, with or without concomitant implantation of cortical strip leads, to determine the ability to detect electrographic seizures in the thalamus. Detailed patient presentations and lead trajectories were reviewed alongside electroencephalographic analyses.ResultsAnterior nucleus thalamic leads, whether bilateral or unilateral and combined with a cortical strip lead, successfully detected and terminated epileptiform activity, as demonstrated by Cases 2 and 3. Similarly, bilateral centromedian thalamic leads or a combination of one centromedian thalamic alongside a cortical strip lead also demonstrated the ability to detect electrographic seizures as seen in Cases 6 and 9. Bilateral pulvinar leads likewise produced reliable seizure detection in Patient 14. Detections of electrographic seizures in thalamic nuclei did not appear to be affected by whether the patient was pediatric or adult at the time of RNS System implantation. Sole thalamic leads paralleled the combination of thalamic and cortical strip leads in terms of preventing the propagation of electrographic seizures.ConclusionThalamic nuclei present a promising target for detection and stimulation via the RNS System for seizures with multifocal or generalized onsets. These areas provide a modifiable, reversible therapeutic option for patients who are not candidates for surgical resection or ablation. (shrink)

This book updates and adds to the classic Social Movements of the Sixties and Seventies, showing how social movement theory has grown and changed.

This article critically examines the practice of unnamed sourcing in journalism. A literature review highlights arguments in favor of and against their use. The authors examine some common examples of anonymous sourcing using the lens of utilitarianism, the ethical model commonly used to justify the practice. We find that few uses of unnamed sourcing can be justified when weighed against diminished credibility and threats to fair, transparent reporting. The authors suggest specific guidelines for journalists that, if followed, would curb many (...) of the pedestrian uses of unnamed sourcing but still allow for the practice in specific circumstances. (shrink)

Drawing on the distinction between dominance and prestige as two evolutionarily grounded strategies for attaining status in human groups, this essay examines an underappreciated feature of Donald Trump's appeal to the millions of American voters who elected him president in 2016—his uncanny ability to channel primal dominance. Like the alpha male of a chimpanzee colony, Trump leads through intimidation, bluster, and threat, and through the establishment of short-term, opportunistic relationships with other high-status agents. Whereas domain-specific expertise confers status in the (...) prestige paradigm, dominant leaders derogate expertise in order to establish a direct, authoritarian connection to their constituency. Trump's leadership style derives readily from his personality makeup, which entails a combustible temperament mixture of high extraversion and low agreeableness, a motivational agenda centered on extreme narcissism, and an internalized life story that tracks the exploits of an intrepid warrior who must forever fight to win in a Hobbesian world of carnage. (shrink)

Since the publication of The Sexual Politics of Meat in 1990, activist and writer Carol J. Adams (2000 [1990]) has put forth a feminist defence of veganism based on the argument that meat consumption and violence against animals are structurally related to violence against women, and especially to pornography and prostitution. Adams’ work has been influential in the growing fields of animal studies and posthumanism, where her research is frequently cited as the prime example of vegan feminism. However, her particular (...) radical feminist framework, including her anti-pornography and anti-prostitution arguments, are rarely acknowledged or critiqued. This article challenges the premises of Adams’ argument, demonstrating that her version of vegan feminism is based upon an unsubstantiated comparison between violence against women and violence against other-than-human animals, and on the silencing and exclusion of sex workers as subjects. The article contests the limited reading of Adams, and of feminism, offered in some key works in animal studies and posthumanism, at the same time that it recognises the need to challenge the anthropocentrism evident in much feminist theory. By way of alternative approaches to the sexual politics of veganism, the article highlights the interventions of artist and activist Mirha-Soleil Ross, proposing that her situated and embodied commitment to animal rights brings sex worker agency into the story, while resisting simple comparisons among different forms of violence. The concerns raised by Ross overlap in compelling ways with recent research in performance studies and labour history, bringing the question of work and workers, animal and human, to the fore. These studies point towards a potentially more useful framework than that of Adams for understanding the human violence suffered by different species, including those destined to be eaten by people. (shrink)

This bibliography carries on the work of Jens Himmelstrups international bibliography from 1962.

This paper is devoted to the study of some subvarieties of the variety Qof Q-Heyting algebras, that is, Heyting algebras with a quantifier. In particular, a deeper investigation is carried out in the variety Q 3 of three-valued Q-Heyting algebras to show that the structure of the lattice of subvarieties of Qis far more complicated that the lattice of subvarieties of Heyting algebras. We determine the simple and subdirectly irreducible algebras in Q 3 and we construct the lattice of subvarieties (...) (Q 3 ) of the variety Q 3. (shrink)

This paper is devoted to the study of some subvarieties of the variety Q of Q-Heyting algebras, that is, Heyting algebras with a quantifier. In particular, a deeper investigation is carried out in the variety Q subscript 3 of three-valued Q-Heyting algebras to show that the structure of the lattice of subvarieties of Q is far more complicated that the lattice of subvarieties of Heyting algebras. We determine the simple and subdirectly irreducible algebras in Q subscript 3 and we construct (...) the lattice of subvarieties lambda (Q subscript 3) of the variety Q subscript 3. (shrink)

Nineteenth-century philosophers, including J.S. Mill, Karl Marx, and Friedrich Nietzsche, criticized Jeremy Bentham for his supposed aesthetic insensibility to the arts, especially literature. Through analysis of Bentham’s manuscript comments on novelists, both negative and positive, this essay analyzes the pleasure Bentham took in fictional narratives in the context of his advocacy for sexual and gender minorities, disabled persons, colonized and enslaved persons, children, and animals. Drawing from a wide range of Bentham’s papers, the author then focuses on a vivid manuscript (...) proposing ‘a new and improved Drama,’ in which Bentham examines the desire to be immersed in an interactive dramatic experience of one’s favorite works of fiction. (shrink)

Where does the mind stop and the rest of the world begin? The question invites two standard replies. Some accept the demarcations of skin and skull, and say that what is outside the body is outside the mind. Others are impressed by arguments suggesting that the meaning of our words "just ain't in the head", and hold that this externalism about meaning carries over into an externalism about mind. We propose to pursue a third position. We advocate a very different (...) sort of externalism: an _active externalism_, based on the active role of the environment in driving cognitive processes. (shrink)

Chapter III contains several puzzles and unexpected features. The first puzzle regards the chapter’s relationship to Chapter IV: Natural Selection. Both chapters treat of natural selection, so what distinguishes them? Is it that Chapter IV indicates the intelligence behind nature’s selections and Chapter III introduces the analog of intelligence? And is it that Chapter III suggests that natural selection performs an eliminative function, while Chapter IV shows the positive impact of selection? In Chapter IV, and in many subsequent chapters, natural (...) selection, Darwin says, operates only for the good of each individual creature, though Chapter III suggests it destroys most individuals. Darwin asserts that he uses the term “struggle” metaphorically, which raises the question of the explanatory weight his metaphors carry, such metaphors as "the face of nature.” There are a number of unexpected features of Darwin’s analysis displayed in the chapter: for example, his introduction of a new concept of the selective environment and the several experiments he performs to establish his theory, e.g., from mathematical and thought experiments to controlled empirical experiments. Chapter III is a rich though puzzling chapter. (shrink)

Continuing the dialogue: postcolonial feminist scholarship and Bourdieu — discourses of culture and points of connection Postcolonial feminist theories provide the analytic tools to address issues of structural inequities in groups that historically have been socially and economically disadvantaged. In this paper we question what value might be added to postcolonial feminist theories on culture by drawing on Bourdieu. Are there points of connection? Like postcolonial feminists, he puts forward a position that aims to unmask oppressive structures. We argue that, (...) while there are points of connection, there are also epistemologic and methodologic differences between postcolonial feminist perspectives and Bourdieu's work. Nonetheless, engagement with different theoretical perspectives carries the promise of new insights — new ways of ‘seeing’ and ‘understanding’ that might enhance a praxis‐oriented theoretical perspective in healthcare delivery. (shrink)

The EDPS Ethics Advisory Group (EAG) has carried out its work against the backdrop of two significant social-political moments: a growing interest in ethical issues, both in the public and in the private spheres and the imminent entry into force of the General Data Protection Regulation (GDPR) in May 2018. For some, this may nourish a perception that the work of the EAG represents a challenge to data protection professionals, particularly to lawyers in the field, as well as to companies (...) struggling to adapt their processes and routines to the requirements of the GDPR. What is the purpose of a report on digital ethics, if the GDPR already provides all regulatory requirements to protect European citizens with regard to the processing of their personal data? Does the existence of this EAG mean that a new normative ethics of data protection will be expected to fill regulatory gaps in data protection law with more flexible, and thus less easily enforceable ethical rules? Does the work of the EAG signal a weakening of the foundation of legal doctrine, such as the rule of law, the theory of justice, or the fundamental values supporting human rights, and a strengthening of a more cultural approach to data protection? Not at all. The reflections of the EAG contained in this report are not intended as the continuation of policy by other means. It neither supersedes nor supplements the law or the work of legal practitioners. Its aims and means are different. On the one hand, the report seeks to map and analyse current and future paradigm shifts which are characterised by a general shift from analogue experience of human life to a digital one. On the other hand, and in light of this shift, it seeks to re-evaluate our understanding of the fundamental values most crucial to the well-being of people, those taken for granted in a data-driven society and those most at risk. The objective of this report is thus not to generate definitive answers, nor to articulate new norms for present and future digital societies but to identify and describe the most crucial questions for the urgent conversation to come. This requires a conversation between legislators and data protection experts, but also society at large - because the issues identified in this report concern us all, not only as citizens but also as individuals. They concern us in our daily lives, whether at home or at work and there isn’t a place we could travel to where they would cease to concern us as members of the human species. (shrink)

This is an examination of the significance of Gandhi's social philosophy for development. It is argued that, when seen in light of Gandhi's social philosophy, the concepts of appropriate technology and basic needs take on new meaning. The Gandhian approach can be identified with theoriginal "basic needs" strategy for international development. Gandhi's approach helps to provide greater equity, or "distributive justice," by promoting technology that is appropriate to "basic needs". Gandhi's social philosophy has been neglected by most development specialists, with (...) only a few exceptions. This analysis attempts to draw out some aspects of M.K. Gandhi's background and his thinking aboutswadeshi andswaraj. Gandhi's ideas, which emerged out of an "Indic" meta-cultural background, are based on an emphasis on equity. Gandhi's syncretic Indic background includes a belief in what Bateson, writing about Bali, Indonesia, has called the "steady state." Development activities should be carried out in a phased manner that does not disturb the beneficial aspects of dynamic equilibrium, but that does promote "positive development." A.T. is particularly useful within the context of a basic needs approach to international development because use of A.T. is probably more likely to lead to equitable growth. The "economic growth" strategy, utilizing "advanced technology" exclusively, has caused unemployment and has not led to effective "trickle down," much less "high mass consumption." In many developing countries the poorest 20% of the population are worse off in 1990 than they were in 1980. By making use of the "advantage of backwardness" and viewing development in terms of long-term impacts, a basic needs approach using A.T. is more likely to lead to a positive impact on third world food systems than a pure "economic growth" strategy. (shrink)

Excerpt from Studies in Human Nature The aim of these studies is to examine with all possible freedom from theoretical bias some phases of human nature which are of great interest in themselves, and in the light of the analysis to draw certain conclusions. It would have been natural to have included in such a series the consideration of certain other aspects of human nature, more especially those which concern morality and civic institutions. Morality and the conditions of citizenship arc (...) in many ways the most important forms of human life which can engage our attention at the present time; and the influence of the recent upheaval in our experience has brought before us many moral problems with a peculiar, and perhaps even a new', prominence. It has seemed better, however, to reserve the consideration of these and kindred subjects for another occasion. It is not the purpose of these papers to defend or support any of the familiarly accepted theories, whether of idealism or realism. Human nature is far more interesting and much more important than any theory, and on that account perhaps is tolerant of many theories. It may be remarked, however, that the momentum which carried forward one peculiar form of idealism - the confident and confiding idealism of a generation ago - seems now to have spent its force; and that a realism which takes the form of a new materialism can hardly claim to be in a position to show a better way. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

The expanded use of genetic testing raises key ethical and policy questions about possible benefits and harms for those receiving disease‐risk information. As predictive testing for Huntington’s was initiated in a clinical setting, survey research posing hypothetical test scenarios suggested that the vast majority of at‐risk relatives wanted to know whether they carried a disease‐causing mutation. However, only a small minority ultimately availed themselves of this opportunity. Many at‐risk individuals concluded that a positive test result would be too psychologically overwhelming. (...) A substantial literature suggests that individuals are often more resilient than anticipated in coping with many different health‐related stresses. Much of my own work in the field has been through the Risk Evaluation & Education for Alzheimer’s Disease study (REVEAL), a series of randomized clinical trials assessing the impact of genetic susceptibility testing on asymptomatic individuals at risk for Alzheimer’s disease. Our experience in developing and implementing four successive, multisite trials provides some potentially useful lessons for the field. More people will be asking for their personal genetic information. Better understanding will help us decide when access is appropriate and how best to disclose results in a manner that supports adjustment to test findings and promotes use of genetic information to improve human health. (shrink)

The introduction of the trireme into Greek navies was an event of great political importance, which may fairly be compared to the introduction of the ‘all-big-gun’ battleship into the British Navy in 1907. Heavier, more powerful, and capable of carrying more πιβται, but making greater demands on timber supplies and manpower, the trireme not only rendered obsolete all existing Greek line-of-battle ships but gave a decisive advantage to those States whose resources in materials and men enabled them to create and (...) maintain adequate fleets of the new type of warship.1 It is a mark of the insufficiency of our sources for early Greek history that we nowhere find an explicit statement of the date at which this revolution occurred, or of the identity of the person responsible. (shrink)

The transference of preservation results between importing and unconstrained fibring is investigated. For that purpose, a new formulation of fibring, called biporting, is introduced, and importing is shown to be subsumed by biporting. In consequence, particular cases of importing, like temporalization, modalization and globalization are subsumed by fibring. Capitalizing on these results, the preservation of the finite model property by fibring is transferred to importing and then carried over to globalization.

Consideration of the experimental activities carried out in one discipline, through the lens of another, can lead to novel insights. Here, we comment from a biological perspective upon experiments in quantum mechanics proposed by physicists that are likely to feasible in the near future. In these experiments, an entire living organism would be knowingly placed into a coherent quantum state for the first time, i.e. would be coerced into demonstrating quantum phenomena. The implications of the proposed experiment for a biologist (...) depend to an extent upon the outcomes. If successful, then the organism will have been temporarily in a state where it has an unmeasurable metabolism—not because a metabolic rate is undetectable, but because any attempt to measure it would automatically bring the organism out of the state. We argue that this would in essence represent a new category of cryptobiosis. Further, the organism would not necessarily retain all of the characteristics commonly attributed to living systems, unlike the currently known categories of cryptobiosis. If organisms can survive having previously been in a coherent state, then we must accept that living systems do not necessarily need to remain in a decoherent state at all times. This would be something new to biologists, even if it might seem trivial to physicists. It would have implications concerning the physical extremes organisms can tolerate, the search for extraterrestrial life, and our philosophical view of animation. (shrink)

Two theses figure centrally in work on the epistemology of disagreement: Equal Weight (‘EW’) and Uniqueness (‘U’). According to EW, you should give precisely as much weight to the attitude of a disagreeing epistemic peer as you give to your own attitude. U has it that, for any given proposition and total body of evidence, some doxastic attitude is the one the evidence makes rational (justifies) toward that proposition. Although EW has received considerable discussion, the case for U has not (...) been critically evaluated. Endorsing U, we argue, commits one to the highly controversial thesis that whatever fixes your rational attitudes can do so only by fixing what evidence you have. This commitment imposes a relatively demanding requirement on justified belief in U, one that we argue is not satisfied by what is currently the strongest available case for U, due to Roger White [2005]. Our challenge to U makes more trouble for its proponents than do the worries about U expressed by Gideon Rosen [2001] and Thomas Kelly [2010]. Moreover, if Kelly [2010] is correct in thinking that EW “carries with it a commitment to” U—a claim which we accept for reasons similar to Kelly’s but is beyond this paper’s scope (but see Ballantyne and Coffman [forthcoming])—then our challenge to U bears importantly on EW: to the extent that our challenge to U succeeds, EW also suffers. (shrink)

No pre-Socratic philosopher, perhaps, has caused more disagreement, or been more variously interpreted, than Anaxagoras of Clazomenae. Among recent attempts to reconstruct his system some of the more notable are those of Tannery, Bailey, Cornford, Peck, and Vlastos. Each of these reconstructions, and especially that of Tannery, has its adherents; and since none of them has much in common with any other, a universally acceptable solution to the fundamental problems involved may well by now seem unattainable. It is my belief, (...) however, and it is the object of this paper to try to prove, that all these modern reconstructions have at least one quality in common, namely an undue complication. The actual system of Anaxagoras was, I believe, considerably simpler than any reconstruction yet forthcoming. Unfortunately what I take to be the basis of the whole system, Anaxagoras' reaction to his Eleatic predecessors, is by.no means easy to convey in brief and simple terms. But if I should succeed in conveying it, then it will, I hope, be seen in itself to possess such a simplicity and neatness that my contention will carry with it a fair warrant of its own truth. I shall, for convenience, divide my argument into ten sections, to which I shall append a brief summary of my conclusions. (shrink)

No pre-Socratic philosopher, perhaps, has caused more disagreement, or been more variously interpreted, than Anaxagoras of Clazomenae. Among recent attempts to reconstruct his system some of the more notable are those of Tannery, Bailey, Cornford, Peck, and Vlastos. Each of these reconstructions, and especially that of Tannery, has its adherents; and since none of them has much in common with any other, a universally acceptable solution to the fundamental problems involved may well by now seem unattainable. It is my belief, (...) however, and it is the object of this paper to try to prove, that all these modern reconstructions have at least one quality in common, namely an undue complication. The actual system of Anaxagoras was, I believe, considerably simpler than any reconstruction yet forthcoming. Unfortunately what I take to be the basis of the whole system, Anaxagoras' reaction to his Eleatic predecessors, is by.no means easy to convey in brief and simple terms. But if I should succeed in conveying it, then it will, I hope, be seen in itself to possess such a simplicity and neatness that my contention will carry with it a fair warrant of its own truth. I shall, for convenience, divide my argument into ten sections, to which I shall append a brief summary of my conclusions. (shrink)

The medium‐independence of computational descriptions has shaped common conceptions of computational explanation. So long as our goal is to explain how a system successfully carries out its computations, then we only need to describe the abstract series of operations that achieve the desired input–output mapping, however they may be implemented. It is argued that this abstract conception of computational explanation cannot be applied to so‐called real‐time computing systems, in which meeting temporal deadlines imposed by the systems with which a device (...) interfaces are constitutive of the computing tasks that a device performs. Instead, real‐time computing reveals the need for alternative conceptions of computational explanation, as well as computational implementation, that eschew medium‐independence. (shrink)

In a reflective and richly entertaining piece from 1979, Doug Hofstadter playfully imagined a conversation between ‘Achilles’ and an anthill (the eponymous ‘Aunt Hillary’), in which he famously explored many ideas and themes related to cognition and consciousness. For Hofstadter, the anthill is able to carry on a conversation because the ants that compose it play roughly the same role that neurons play in human languaging; unfortunately, Hofstadter’s work is notably short on detail suggesting how this magic might be achieved1. (...) Conversely in this paper - finally reifying Hofstadter’s imagination - we demonstrate how populations of simple ant-like creatures can be organised to solve complex problems; problems that involve the use of forward planning and strategy. Specifically we will demonstrate that populations of such creatures can be configured to play a strategically strong - though tactically weak - game of HeX (a complex strategic game).We subsequently demonstrate how tactical play can be improved by introducing a form of forward planning instantiated via multiple populations of agents; a technique that can be compared to the dynamics of interacting populations of social insects via the concept of meta-population. In this way although, pace Hofstadter, we do not establish that a meta-population of ants could actually hold a conversation with Achilles, we do successfully introduce Aunt Hillary to the complex, seductive charms of HeX. (shrink)

Abstract Do the central aims of epistemology, like those of moral philosophy, require that we designate some important place for those concepts located between the thin-normative and the non-normative? Put another way, does epistemology need "thick" evaluative concepts and with what do they contrast? There are inveterate traditions in analytic epistemology which, having legitimized a certain way of viewing the nature and scope of epistemology's subject matter, give this question a negative verdict; further, they have carried with them a tacit (...) commitment to what we argue to be an epistemic analogue of the reductionistic centralist thesis which Bernard Williams, in our view, successfully repudiates in ethics. In this essay, we challenge the epistemic analogue of the traditional but mistaken thesis. In offering an alternative to it which provides a comfortable home for the epistemic normativity which attends thick evaluative concepts, we align ourselves with what has been recently called the Value Turn in epistemology. From this perspective, we defend that, contrary to tradition, as influenced by centralist assumptions, epistemology does need thick evaluative concepts. Further, the sort of theories that will be able to give thick evaluative concepts an irreducible role in both belief and agent evaluation are adequately social epistemologies. What loosely refer to as second-wave of virtue epistemology is the widespread interest to provide a comfortable home for the role of thick normativity, as it is connected both with epistemic evaluation, and guidance. We recognize that, in breaking from centralism, there is a worry that a resulting anti-centralist theory will be reductionistic in the other direction, making the thick primary. We contend however that second-wave virtue epistemologies take different sources of social and epistemic value into account; they seek the 'right thickness' to ride with conception of epistemology and a field which due in part to virtue theory's resurgence, is today normative, diverse and expansive than was the traditional set of problems from which it emerged. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:45. HUME'S DIFFICULTIES WITH THE SELF One of the more baffling and apparently inconclusive parts of the Treatise is the section on personal identity. Hume himself, when he takes a backward glance at it in those notorious passages in the Appendix, singles it out as representing an unresolved problem in his philosophy. It is a matter of fairly general agreement among recent writers on the subject that one of (...) Hume's chief difficulties -- though not one he recognizes — is his assigning to the mind (or, sometimes, the "imagination") certain activities, which he claims are instrumental in generating belief in, and awareness of, the very mind or self whose activities they are said to be. Hume talks about customs and habits of the mind and the expectations arising out of these, of the acts of observing, noticing and associating, of believing, of feigning, and so on, acts which the mind is required to perform in order for us to be able to explain along acceptable empiricist lines how the idea of an abiding self arises. Such talk, it seems, already presupposes the existence of a self and our possession of the idea thereof. So does, of course, the talk involved in Hume's accounts of the external world and of causality. Insofar as these involve his theory of belief, they, too, seem to presuppose a self which is more than a fiction, more than a product of the imagination. Yet the account he gives of the self seems to yield precisely a fiction in just the sense in which our ideas of the external world and of its causal connections are ideas of fictions. Quite generally, then, if Hume's theory of belief presupposes a continually existing self, what sense can be made of his arguments to show that our belief in such a self is the belief in a fiction? I want to argue that Hume can be defended against such criticisms and that the appearance of circularity here is just that: an appearance. It results largely from 46. two features of the Treatise. The first is that since at different points in the Treatise Hume is obviously concerned with different problems, his language reflects this. It is for this reason only that at times he talks in ways which make it seem that a continually existing self is being presupposed. The second feature responsible for the appearance of circularity is that while Hume draws a distinction between "perfect" and 'imperfect" identity, he fails to make that distinction explicit enough, so that one may easily miss the all-important point that it is only the former sort of identity which is being denied of the self, and the latter sort which is being explained and accounted for along Humean empiricist lines. If we keep this in mind, we shall see that the references in his account of the identity of the self to the activities of the self are not questionbegging, and that the attribution of these activities to the very same "fiction" whose existence is being accounted for carries no absurdity. II One way to bring out the differences between the kind of self which is alleged to be presupposed by Hume's account and that which, as I shall argue, is really involved in that account, is to put pressure on Hume's doctrine of 2 association. It is frequently urged by commentators that the notion of association which is so fundamental for much of Hume's philosophy is ambiguous, showing as it does the influence of two very different models, deriving from Hutcheson and Newton respectively. On the first model, a continuing self is presupposed as the agent of the various sorts of associative acts he invokes; on the second it is the items associated (perceptions) which are themselves the entities doing the associating. Clearly, the question whether Hume's theory of belief involves the assumption that a continuing self exists (harmless in the uses of that 47. theory in other contexts, but possibly fatal in its use in a theory of personal identity) may be seen to resolve into the question, which model of association is fundamental for Hume? It is, of course, an undeniable... (shrink)

Over the course of a long and distinguished career, psychologist and psychoanalyst Sidney J. Blatt has made major contributions to cognitive-developmental theory, psychoanalytic object relations theory, applied psychoanalysis, and current research in the areas of psychopathology and psychotherapy. This book presents chapters by Dr. Blatt's many colleagues and students who address the key areas in which Dr Blatt focuses his intellectual endeavours: *Personality development *Psychopathology *Issues in psychological testing and assessment *Psychotherapy and the treatment process *Applied psychoanalysis and broader cultural (...) trends _Relatedness, Self-Definition and Mental Representation_ explores Dr. Blatt's unique contributions within both psychoanalysis, where empirical research is often neglected, and clinical psychology, where psychoanalysis is increasingly ignored. It will be engaging reading for psychoanalysts and clinical psychologists, as well as all those concerned with psychotherapy and personality theory and development. (shrink)